The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

By general consensus, the omnipresent purine nucleoside adenosine is considered a major
regulator of local tissue function, especially when energy supply fails to meet cellular energy …

The A3 adenosine receptor (A3AR) subtype is a novel, promising therapeutic target for
inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver …

Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

Imiquimod, a small-molecule immune response modifier of the imidazoquinoline family, has
shown profound antitumoral and antiviral efficacy both in vitro and in clinical applications in …

Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-
coupled membrane receptors, designated A1, A2A, A2B and A3. Adenosine plays an …

Efforts to fully understand pharmacological differences between G protein-coupled receptor
(GPCR) species homologues are generally not pursued in detail during the drug …

Intense efforts of many pharmaceutical companies and academicians in the A 1 adenosine
receptor (AR) field have led to the discovery of clinical candidates that are antagonists …

Drug addiction is a serious brain disorder with somatic, psychological, psychiatric, socio-
economic and legal implications in the developed world. Illegal (eg, psychostimulants …

Approaches to the synthesis of purine derivatives bearing carbon substituents in positions 2,
6, or 8, mediated and/or catalysed by organometallic compounds and metals, are reviewed …