Oncogenic BRAF alterations and their role in brain tumors

F Behling, J Schittenhelm - Cancers, 2019 - mdpi.com
Alterations of the v-raf murine sarcoma viral oncogene homolog B (BRAF) have been
extensively studied in several tumor entities and are known to drive cell growth in several …

Dysembryoplastic neuroepithelial tumors: what you need to know

S Luzzi, A Elia, M Del Maestro, SK Elbabaa… - World neurosurgery, 2019 - Elsevier
Objective An updated and comprehensive review on dysembryoplastic neuroepithelial
tumor (DNET) focusing on differential diagnosis, atypical presentation, seizure outcome, and …

[HTML][HTML] Differential expression of circular RNAs in glioblastoma multiforme and its correlation with prognosis

J Zhu, J Ye, L Zhang, L Xia, H Hu, H Jiang, Z Wan… - Translational …, 2017 - Elsevier
OBJECTIVE: The present study aimed to explore the expression profiles of circular RNAs
(circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in …

Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours

TJ Stone, A Keeley, A Virasami, W Harkness… - Acta …, 2018 - Springer
Glioneuronal tumours are an important cause of treatment-resistant epilepsy. Subtypes of
tumour are often poorly discriminated by histological features and may be difficult to …

BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons

RU Goz, G Akgül, JJ LoTurco - Journal of Neurophysiology, 2020 - journals.physiology.org
Somatic mutations have emerged as the likely cause of focal epilepsies associated with
developmental malformations and epilepsy-associated glioneuronal tumors (GNT). Somatic …

Clinical characteristics of BRAF V600E gene mutation in patients of epilepsy-associated brain tumor: a meta-analysis

H Xing, Y Song, Z Zhang, PD Koch - Journal of Molecular Neuroscience, 2021 - Springer
Epilepsy-associated brain tumors (EATs) are usually slow-growing, with seizures as the
primary and most dominant symptom. BRAF (v-raf murine sarcoma viral oncogene homolog …

Genome-wide DNA methylation and RNAseq analyses identify aberrant signalling pathways in focal cortical dysplasia (FCD) type II

AB Dixit, D Sharma, M Tripathi, A Srivastava, D Paul… - Scientific Reports, 2018 - nature.com
Focal cortical dysplasia (FCD) is one of the most common pathologies associated with drug-
resistant epilepsy (DRE). The pharmacological targets remain obscured, as the molecular …

Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course

D Delev, K Daka, S Heynckes, A Gaebelein… - Scientific Reports, 2020 - nature.com
Long-term epilepsy-associated tumors (LEATs) represent mostly benign brain tumors
associated with drug-resistant epilepsy. The aim of the study was to investigate the specific …

Relationship among clinical, pathological and bio-molecular features in low-grade epilepsy-associated neuroepithelial tumors

G Vornetti, G Marucci, C Zenesini, D De Biase… - Journal of Clinical …, 2017 - Elsevier
The aim of this study was to evaluate the relationship between molecular markers and
clinicopathological features in patients operated on for low-grade epilepsy-associated …

The essentials of molecular testing in CNS tumors: what to order and how to integrate results

AZ Feldman, LJ Jennings, NR Wadhwani… - Current neurology and …, 2020 - Springer
Abstract Purpose of Review Molecular testing has become essential for the optimal workup
of central nervous system (CNS) tumors. There is a vast array of testing from which to …