Treatment-resistant depression revisited: a glimmer of hope

A Halaris, E Sohl, EA Whitham - Journal of personalized medicine, 2021 - mdpi.com
Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It
causes individual suffering, loss of productivity, increased health care costs and high suicide …

Ketamine's mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine's antidepressant effects?

B Quintanilla, CA Zarate Jr, A Pillai - Molecular Psychiatry, 2024 - nature.com
Over 300 million people worldwide suffer from major depressive disorder (MDD).
Unfortunately, only 30–40% of patients with MDD achieve complete remission after …

Ultrasensitive Terahertz Biodetection Enabled by Quasi‐BIC‐Based Metasensors

R Wang, L Xu, L Huang, X Zhang, H Ruan, X Yang… - Small, 2023 - Wiley Online Library
Advanced sensing devices, highly sensitive, and reliable in detecting ultralow
concentrations of circulating biomarkers, are extremely desirable and hold great promise for …

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

Y Milaneschi, N Kappelmann, Z Ye, F Lamers… - Molecular …, 2021 - nature.com
We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …

Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19

N Kappelmann, R Dantzer, GM Khandaker - Psychoneuroendocrinology, 2021 - Elsevier
The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such
as fatigue, sleeping difficulties, depression and anxiety. We propose that neuroimmune …

The future is dynamic: A call for intensive longitudinal data in immunopsychiatry

DP Moriarity, GM Slavich - Brain, behavior, and immunity, 2023 - Elsevier
The long-term value of immunopsychiatry will be based on its ability to translate basic
science into effective clinical interventions. In this article, we discuss a key obstacle to …

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study

N Kappelmann, D Czamara, N Rost, S Moser… - Brain, Behavior, and …, 2021 - Elsevier
Background About every fourth patient with major depressive disorder (MDD) shows
evidence of systemic inflammation. Previous studies have shown inflammation-depression …

Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study

L Sforzini, A Cattaneo, C Ferrari, L Turner… - Translational …, 2023 - nature.com
Compelling evidence demonstrates that some individuals suffering from major depressive
disorder (MDD) exhibit increased levels of inflammation. Most studies focus on inflammation …

A network analysis of depressive symptoms and metabolomics

AO Rydin, Y Milaneschi, R Quax, J Li… - Psychological …, 2023 - cambridge.org
BackgroundDepression is associated with metabolic alterations including lipid
dysregulation, whereby associations may vary across individual symptoms. Evaluating these …

[HTML][HTML] Personality pathways to mortality: Interleukin-6 links conscientiousness to mortality risk

PS O'Súilleabháin, NA Turiano, D Gerstorf… - Brain, behavior, and …, 2021 - Elsevier
Personality is associated consistently with mortality hazards, but the physiological pathways
are not yet clear. Immune system dysregulation may be one such pathway due to its role in …