Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward
approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF …

Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

I am a chemist and engineer who looks upon the living world with the deepest admiration.
Nature, herself a brilliant chemist and by far the best engineer of all time, invented life that …

Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is
beginning to transform chemical synthesis in the pharmaceutical industry. This review …

The generation of enantiodivergent biocatalysts for C–H oxyfunctionalizations is ever more
important in modern synthetic chemistry. Here, we have applied the FuncLib algorithm …