Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and
beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT …

ABSTRACT Background Neuregulin 4 (Nrg4) is a brown adipose tissue-derived adipokine
that greatly affects systemic metabolism and improves metabolic derangements. Although …

Disruption of ciliary homeostasis in vascular endothelial cells has been implicated in the
development of atherosclerosis. However, the molecular basis for the regulation of …

Metabolic dysfunction-associated steatohepatitis (MASH, previously termed non-alcoholic
steatohepatitis (NASH)), is a major complication of obesity that promotes fatty liver disease …

BACKGROUND: Inflammation contributes to the pathogenesis of atherosclerosis. But little is
known about the potential benefits of inflammatory cells to atherosclerosis. The aim of this …

Adipokines are biologically active factors secreted by adipose tissue that act on local and
distant tissues through autocrine, paracrine, and endocrine mechanisms. However …

Abstract Neuregulin 4 (Nrg4), an epidermal growth factor (EGF) family member, can bind to
and activate the ErbB4 receptor tyrosine kinase. Nrg4 has five different isoforms by …

BACKGROUND: Cellular communication among different types of vascular cells is
indispensable for maintaining vascular homeostasis and preventing atherosclerosis …

Most blood vessels are surrounded by adipose tissues known as perivascular adipose
tissue (PVAT). Emerging experimental data have implicated the potential involvement of …

Acute myocardial infarction (AMI) and related cardiovascular disease complications are the
leading causes of mortality worldwide. Brown adipose tissue (BAT) is thermogenic and …