The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

P Lacolley, V Regnault, A Nicoletti, Z Li… - Cardiovascular …, 2012 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, continually
exposed to mechanical signals and biochemical components generated in the blood …

Smooth muscle cell and arterial aging: basic and clinical aspects

P Lacolley, V Regnault, AP Avolio - Cardiovascular research, 2018 - academic.oup.com
Arterial aging engages a plethora of key signalling pathways that act in concert to induce
vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration …

TGF-β superfamily signaling in the eye: implications for ocular pathologies

S Hachana, B Larrivée - Cells, 2022 - mdpi.com
The TGF-β signaling pathway plays a crucial role in several key aspects of development and
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …

The role of endoglin and its soluble form in pathogenesis of preeclampsia

G Margioula-Siarkou, C Margioula-Siarkou… - Molecular and Cellular …, 2022 - Springer
Preeclampsia remains till today a leading cause of maternal and fetal morbidity and
mortality. Pathophysiology of the disease is not yet fully elucidated, though it is evident that it …

Myocardin in biology and disease

JM Miano - Journal of biomedical research, 2014 - pmc.ncbi.nlm.nih.gov
Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac
muscle and smooth muscle through direct contacts with serum response factor (SRF) over …

INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10

W Zhang, J Zhao, L Deng, N Ishimwe, J Pauli, W Wu… - Circulation, 2023 - Am Heart Assoc
Background: Activation of vascular smooth muscle cell (VSMC) inflammation is vital to
initiate vascular disease. The role of human-specific long noncoding RNAs in VSMC …

AK098656, a novel vascular smooth muscle cell–dominant long noncoding RNA, promotes hypertension

L Jin, X Lin, L Yang, X Fan, W Wang, S Li, J Li, X Liu… - …, 2018 - Am Heart Assoc
Recent studies reported some long noncoding RNAs (lncRNAs)–mediated vascular smooth
muscle cells (VSMCs) phenotypic switch, which was a common pathophysiological process …

MYOSLID Is a Novel Serum Response Factor–Dependent Long Noncoding RNA That Amplifies the Vascular Smooth Muscle Differentiation Program

J Zhao, W Zhang, M Lin, W Wu, P Jiang… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Long noncoding RNAs (lncRNA) represent a growing class of noncoding genes
with diverse cellular functions. We previously reported on SENCR, an lncRNA that seems to …

MicroRNAs regulate vascular smooth muscle cell functions in atherosclerosis

X Yu, Z Li - International journal of molecular medicine, 2014 - spandidos-publications.com
Vascular smooth muscle cells (VSMCs) are involved in all stages of the progression of
human atherosclerosis (AS). MicroRNAs (miRNAs or miRs) are non‑coding, small RNAs that …

Lipotoxicity, glucotoxicity and some strategies to protect vascular smooth muscle cell against proliferative phenotype in metabolic syndrome

O López-Acosta, A Ruiz-Ramírez… - Food and Chemical …, 2023 - Elsevier
Metabolic syndrome (MetS) is a risk factor for the development of cardiovascular disease
(CVD) and atherosclerosis through a mechanism that involves vascular smooth muscle cell …