The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Gene-disruptive mutations contribute to the biology of neurodevelopmental disorders
(NDDs), but most of the related pathogenic genes are not known. We sequenced 208 …

A small number of rare, recurrent genomic copy number variants (CNVs) are known to
substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity …

Understanding the cellular and molecular mechanisms underlying the formation and
maintenance of memories is a central goal of the neuroscience community. It is well …

Mutations in more than 450 different genes have been associated with intellectual disability
(ID) and related cognitive disorders (CDs), such as autism. It is to be expected that this …

Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
developmental disorders present in humans. Combined, they affect between 3 and 5% of …

Long-term memory formation requires transcription and protein synthesis. Over the past few
decades, a great amount of knowledge has been gained regarding the molecular players …

Kleefstra syndrome (KS) is a neurodevelopmental disorder caused by mutations in the
histone methyltransferase EHMT1. To study the impact of decreased EHMT1 function in …

Intellectual disability (ID) disorders are genetically and phenotypically highly heterogeneous
and present a major challenge in clinical genetics and medicine. Although many genes …