Insertions and Deletions: Computational Methods, Evolutionary Dynamics, and Biological Applications
Insertions and deletions constitute the second most important source of natural genomic
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …
A probabilistic model for indel evolution: differentiating insertions from deletions
G Loewenthal, D Rapoport, O Avram… - Molecular biology …, 2021 - academic.oup.com
Insertions and deletions (indels) are common molecular evolutionary events. However,
probabilistic models for indel evolution are under-developed due to their computational …
probabilistic models for indel evolution are under-developed due to their computational …
The evolutionary traceability of a protein
A Jain, D Perisa, F Fliedner… - Genome biology and …, 2019 - academic.oup.com
Orthologs document the evolution of genes and metabolic capacities encoded in extant and
ancient genomes. However, the similarity between orthologs decays with time, and …
ancient genomes. However, the similarity between orthologs decays with time, and …
Multiple sequence alignment averaging improves phylogeny reconstruction
The classic methodology of inferring a phylogenetic tree from sequence data is composed of
two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is …
two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is …
Simulation of chordate intron evolution using randomly generated and mutated base sequences
GD Wang, Y Wang, Z Zeng, JM Mao… - Evolutionary …, 2020 - journals.sagepub.com
Introns are well known for their high variation not only in length but also in base sequence.
The evolution of intron sequences has aroused broad interest in the past decades. However …
The evolution of intron sequences has aroused broad interest in the past decades. However …