Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Study objective Increasing opioid prescribing has been linked to an epidemic of opioid
misuse. Our objective is to synthesize the available evidence about patient-, prescriber …

Importance Mortality among people with opioid dependence is higher than that of the
general population. Opioid agonist treatment (OAT) is an effective treatment for opioid …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

Background There has been international concern over the rise in fatal pharmaceutical
opioid overdose rates, driven by increased opioid analgesic prescribing. The current study …

In recent years, long-term prescribing and use of strong opioids for chronic noncancer pain
(CNCP) has increased in high-income countries. Yet existing uncertainties, controversies …

Methods We followed the process of developing class-specific medication deprescribing
guidelines, 17 and the Appraisal of Guidelines for Research and Evaluation (AGREE) II …

Neuropathic pain arises from injury to the nervous system. Conditions associated with
neuropathic pain are diverse, and lesions and/or pathological changes in the central …

Objectives To examine trends in opioid prescribing in primary care, identify patient and
general practice characteristics associated with long-term and stronger opioid prescribing …

Aims To identify patterns of opioid analgesic use and determine predictors of persistent
opioid use among people without cancer. Methods A population‐based cohort study of …