Drugs and bugs: the gut-brain axis and substance use disorders

S Simpson, R Mclellan, E Wellmeyer, F Matalon… - Journal of Neuroimmune …, 2022 - Springer
Substance use disorders (SUDs) represent a significant public health crisis. Worldwide,
5.4% of the global disease burden is attributed to SUDs and alcohol use, and many more …

Clinical and preclinical evidence for gut microbiome mechanisms in substance use disorders

RS Hofford, DD Kiraly - Biological Psychiatry, 2024 - Elsevier
Substance use disorders are a set of recalcitrant neuropsychiatric conditions that cause
tremendous morbidity and mortality and are among the leading causes of loss of disability …

Altered fecal microbiota composition in individuals who abuse methamphetamine

Y Yang, X Yu, X Liu, G Liu, K Zeng, G Wang - Scientific reports, 2021 - nature.com
As a severe public health problem, methamphetamine (METH) abuse places a heavy
burden on families and society. A growing amount of evidence has indicated communication …

Escalating dose-multiple binge methamphetamine treatment elicits neurotoxicity, altering gut microbiota and fecal metabolites in mice

LJ Chen, X Zhi, KK Zhang, LB Wang, JH Li… - Food and Chemical …, 2021 - Elsevier
Methamphetamine (METH) is an addictive and illegal psychostimulant drug that can cause
multiple organ dysfunction, especially in the central nervous system (CNS). Gut microbiota …

Involvement of gut microbiota in schizophrenia and treatment resistance to antipsychotics

M Manchia, A Fontana, C Panebianco, P Paribello… - Biomedicines, 2021 - mdpi.com
The gut microbiota is constituted by more than 40,000 bacterial species involved in key
processes including high order brain functions. Altered composition of gut microbiota has …

Methamphetamine induces intestinal injury by altering gut microbiota and promoting inflammation in mice

LB Wang, LL Xu, LJ Chen, KK Zhang, QY Zhang… - Toxicology and Applied …, 2022 - Elsevier
Methamphetamine (METH) is a psychostimulant abused worldwide. Its abuse induces
intestinal toxicity. Moreover, the gut microbiota is altered by drugs, which induces intestinal …

[HTML][HTML] Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

J Yang, Z Zhang, Z Xie, L Bai, P Xiong, F Chen… - Biomedicine & …, 2022 - Elsevier
Background Metformin exhibits therapeutic potential in behavioural deficits induced by
methamphetamine (METH) in rats. Emerging studies suggest gut microbiota may impact …

Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal

H Abbas-Egbariya, Y Haberman, T Braun, R Hadar… - Genome Biology, 2022 - Springer
Background Gut microbial alteration is implicated in inflammatory bowel disease but is noted
in other diseases. Systematic comparison to define similarities and specificities is hampered …

BugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures

L Geistlinger, C Mirzayi, F Zohra, R Azhar… - Nature …, 2024 - nature.com
The literature of human and other host-associated microbiome studies is expanding rapidly,
but systematic comparisons among published results of host-associated microbiome …

The gut microbiota as a potential biomarker for methamphetamine use disorder: evidence from two independent datasets

L Liu, Z Deng, W Liu, R Liu, T Ma, Y Zhou… - Frontiers in Cellular …, 2023 - frontiersin.org
Background Methamphetamine use disorder (MUD) poses a considerable public health
threat, and its identification remains challenging due to the subjective nature of the current …