Improved prediction of protein-protein interactions by a modified strategy using three conventional docking software in combination

S Choi, SH Son, MY Kim, I Na, VN Uversky… - International Journal of …, 2023 - Elsevier
Proteins play a crucial role in many biological processes, where their interaction with other
proteins are integral. Abnormal protein-protein interactions (PPIs) have been linked to …

A Cell‐Penetrant Peptide Disrupting the Transcription Factor CP2c Complexes Induces Cancer‐Specific Synthetic Lethality

SH Son, MY Kim, S Choi, JS Kim, YS Lee… - Advanced …, 2023 - Wiley Online Library
Despite advances in precision oncology, cancer remains a global public health issue. In this
report, proof‐of‐principle evidence is presented that a cell‐penetrable peptide (ACP52C) …

[HTML][HTML] Structural and functional insights into CP2c transcription factor complexes

SH Son, MY Kim, E Jo, VN Uversky… - International Journal of …, 2022 - mdpi.com
CP2c, also known as TFCP2, α-CP2, LSF, and LBP-1c, is a prototypic member of the
transcription factor (TF) CP2 subfamily involved in diverse ubiquitous and tissue/stage …

Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis

MY Kim, JS Kim, SH Son, CS Lim, HY Eum… - Nucleic Acids …, 2018 - academic.oup.com
During hematopoiesis, red blood cells originate from the hematopoietic stem cell reservoir.
Although the regulation of erythropoiesis and globin expression has been intensively …

Staufen1-mediated mRNA decay induces Requiem mRNA decay through binding of Staufen1 to the Requiem 3′ UTR

MY Kim, J Park, JJ Lee, DH Ha, J Kim… - Nucleic acids …, 2014 - academic.oup.com
Abstract Requiem (REQ/DPF2) was originally identified as an apoptosis-inducing protein in
mouse myeloid cells and belongs to the novel Krüppel-type zinc finger d4-protein family of …

Combining peptide and DNA for protein assay: CRIP1 detection for breast cancer staging

H Xie, H Li, Y Huang, X Wang, Y Yin… - ACS Applied Materials & …, 2014 - ACS Publications
In this work, a novel method for a protein assay is proposed which uses the specific protein-
binding peptide of the target protein and sequence-specific DNA to interact with the target as …

Assessing the selectivity and efficacy of dihydroquinolinone inhibitors directly targeting the oncogene LSF

JM Biagi - 2017 - open.bu.edu
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the
second leading cause of cancer mortality. Despite the prevalence of HCC, there is only one …

[HTML][HTML] A CAPS-based binding assay provides semi-quantitative validation of protein-DNA interactions

Y Xie, Y Zhang, X Zhao, YG Liu, L Chen - Scientific Reports, 2016 - nature.com
Investigation of protein-DNA interactions provides crucial information for understanding the
mechanisms of gene regulation. Current methods for studying protein-DNA interactions …

[HTML][HTML] A simplified and sensitive immunoprecipitation approach for the analysis of HSF1 in murine liver tissue

R Trivedi, JK Tripathi, B Knopf, GD Manocha… - MethodsX, 2021 - Elsevier
Abstract Heat shock factor 1, HSF1, is one of several family members that recognize
repeated nGAAn sequences associated with the heat shock element of heat shock and other …

Preclinical Assessment of Dihydroquinolinone Inhibitors Directly Targeting Oncogene TFCP2 as Cancer Therapeutics

N Pokharel - 2022 - search.proquest.com
The transcription factor TFCP2 is a pro-oncogenic factor in hepatocellular carcinoma,
colorectal cancer, pancreatic cancer, breast cancer, glioma, rhabdomyosarcoma, squamous …