Targeting Mycobacterium tuberculosis iron-scavenging tools: A recent update on siderophores inhibitors
G Kumar, PA Adhikrao - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …
infectious disease responsible as the most significant cause of mortality and morbidity …
Tackling nontuberculous mycobacteria by repurposable drugs and potential leads from natural products
P Amruta Adhikrao, G Mayuri Motiram… - Current Topics in …, 2024 - benthamdirect.com
Nontuberculous Mycobacteria (NTM) refer to bacteria other than all Mycobacterium species
that do not cause tuberculosis or leprosy, excluding the species of the Mycobacterium …
that do not cause tuberculosis or leprosy, excluding the species of the Mycobacterium …
Rho-dependent transcription termination is the dominant mechanism in Mycobacterium tuberculosis
E Ahmad, A Mitra, W Ahmed, V Mahapatra… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Intrinsic and Rho-dependent transcription termination mechanisms regulate gene
expression and recycle RNA polymerase in bacteria. Both the modes are well studied in …
expression and recycle RNA polymerase in bacteria. Both the modes are well studied in …
Regulatory role of Mycobacterium tuberculosis MtrA on dormancy/resuscitation revealed by a novel target gene-mining strategy
X Fu, X Wan, AA Memon, XY Fan, Q Sun… - Frontiers in …, 2024 - frontiersin.org
Introduction The unique dormancy of Mycobacterium tuberculosis plays a significant role in
the major clinical treatment challenge of tuberculosis, such as its long treatment cycle …
the major clinical treatment challenge of tuberculosis, such as its long treatment cycle …
Machine learning prediction of mycobacterial cell wall permeability of drugs and drug-like compounds
EV Radchenko, GV Antonyan, SK Ignatov, VA Palyulin - Molecules, 2023 - mdpi.com
The cell wall of Mycobacterium tuberculosis and related organisms has a very complex and
unusual organization that makes it much less permeable to nutrients and antibiotics, leading …
unusual organization that makes it much less permeable to nutrients and antibiotics, leading …
Biochemical characterization of Mycobacterial RNA polymerases
SL Cooper, RM Requijo, AL Lucius… - Journal of …, 2024 - journals.asm.org
Tuberculosis is caused by the bacterium Mycobacterium tuberculosis (Mtb). While eukaryotic
species employ several specialized RNA polymerases (Pols) to fulfill the RNA synthesis …
species employ several specialized RNA polymerases (Pols) to fulfill the RNA synthesis …
[HTML][HTML] Structure of a Cyclic Peptide as an Inhibitor of Mycobacterium tuberculosis Transcription: NMR and Molecular Dynamics Simulations
Background and Objectives: A novel antitubercular cyclic peptide, Cyclo (1, 6)-Ac-CLYHFC-
NH2, was designed to bind at the rifampicin (RIF) binding site on the RNA polymerase …
NH2, was designed to bind at the rifampicin (RIF) binding site on the RNA polymerase …
Association between mutations in a thyX-hsdS.1 region and para-aminosalicylic acid resistance in Mycobacterium tuberculosis clinical isolates
R Zeng, L He, B Zhang, Y Hu, J Yu, S Yang… - Emerging Microbes & …, 2023 - Taylor & Francis
Although para-aminosalicylic acid (PAS) has been used to treat tuberculosis agent for
decades, its mechanisms of resistance are still not thoroughly understood. Previously …
decades, its mechanisms of resistance are still not thoroughly understood. Previously …
Nα‐Aroyl‐N‐Aryl‐Phenylalanine Amides: A Promising Class of Antimycobacterial Agents Targeting the RNA Polymerase
RW Seidel, R Goddard, M Lang… - Chemistry & …, 2024 - Wiley Online Library
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains the leading cause of
death from a bacterium in the world. The global prevalence of clinically relevant infections …
death from a bacterium in the world. The global prevalence of clinically relevant infections …
Enhancing the Accuracy of Peripheral Pulmonary Tuberculosis Diagnosis: A Comparative Evaluation of CapitalBioTM Mycobacterium Nucleic Acid Detection Test and …
L Zhou, Y Yong, H Li, Q Hu - Infection and Drug Resistance, 2024 - Taylor & Francis
Purpose The diagnosis of tuberculosis located in the peripheral zone remains challenging
and requires ultrasound bronchoscopy-guided maneuvers. We assessed the precision of …
and requires ultrasound bronchoscopy-guided maneuvers. We assessed the precision of …