The evolution, metabolism and functions of the apicoplast

L Lim, GI McFadden - … of the Royal Society B: Biological …, 2010 - royalsocietypublishing.org
The malaria parasite, Plasmodium falciparum, harbours a relict plastid known as the
'apicoplast'. The discovery of the apicoplast ushered in an exciting new prospect for drug …

The ferredoxin redox system–an essential electron distributing hub in the apicoplast of Apicomplexa

OA Akuh, R Elahi, ST Prigge, F Seeber - Trends in parasitology, 2022 - cell.com
The apicoplast, a relict plastid found in most species of the phylum Apicomplexa, harbors the
ferredoxin redox system which supplies electrons to enzymes of various metabolic pathways …

Genetic architecture of artemisinin-resistant Plasmodium falciparum

O Miotto, R Amato, EA Ashley, B MacInnis… - Nature …, 2015 - nature.com
We report a large multicenter genome-wide association study of Plasmodium falciparum
resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast …

Design and Synthesis of Chalcone Derivatives as Inhibitors of the Ferredoxin — Ferredoxin-NADP+ Reductase Interaction of Plasmodium falciparum: Pursuing New …

H Suwito, Jumina, Mustofa, P Pudjiastuti, MZ Fanani… - Molecules, 2014 - mdpi.com
Some chalcones have been designed and synthesized using Claisen-Schmidt reactions as
inhibitors of the ferredoxin and ferredoxin-NADP+ reductase interaction to pursue a new …

Structural basis for the isotype-specific interactions of ferredoxin and ferredoxin: NADP+ oxidoreductase: an evolutionary switch between photosynthetic and …

F Shinohara, G Kurisu, G Hanke, C Bowsher… - Photosynthesis …, 2017 - Springer
In higher plants, ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) are each present
as distinct isoproteins of photosynthetic type (leaf type) and non-photosynthetic type (root …

Roles of ferredoxin-dependent proteins in the apicoplast of Plasmodium falciparum parasites

RP Swift, K Rajaram, R Elahi, HB Liu, ST Prigge - MBio, 2022 - Am Soc Microbiol
Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form a redox system that is
hypothesized to play a central role in the maintenance and function of the apicoplast …

Plasmodium falciparum acyl carrier protein crystal structures in disulfide‐linked and reduced states and their prevalence during blood stage growth

JR Gallagher, ST Prigge - Proteins: Structure, Function, and …, 2010 - Wiley Online Library
Abstract Acyl Carrier Protein (ACP) has a single reactive sulfhydryl necessary for function in
covalently binding nascent fatty acids during biosynthesis. In Plasmodium falciparum, the …

The ferredoxin‐NADP+ reductase/ferredoxin electron transfer system of Plasmodium falciparum

E Balconi, A Pennati, D Crobu, V Pandini… - The FEBS …, 2009 - Wiley Online Library
In the apicoplast of apicomplexan parasites, plastidic‐type ferredoxin and ferredoxin‐
NADP+ reductase (FNR) form a short electron transport chain that provides reducing power …

Functional analyses of plasmodium ferredoxin Asp97Tyr mutant related to artemisinin resistance of human malaria parasites

Y Kimata-Ariga, R Morihisa - The Journal of Biochemistry, 2021 - academic.oup.com
Abstract Mutation of Asp97Tyr in the C-terminal region of ferredoxin (PfFd) in the apicoplast
of malaria parasites was recently reported to be strongly related to the parasite's resistance …

Effect of artemisinin on the redox system of NADPH/FNR/ferredoxin from malaria parasites

Y Kimata-Ariga, R Morihisa - Antioxidants, 2022 - mdpi.com
FNR and ferredoxin constitute a redox cascade, which provides reducing power in the
plastid of malaria parasites. Recently, mutation of ferredoxin (D97Y) was reported to be …