The T cell infiltrates that are formed in human cancers are a modifier of natural disease
progression and also determine the probability of clinical response to cancer …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

The majority of colorectal cancer patients are not responsive to immune checkpoint
blockade (ICB). The interferon gamma (IFNγ) signaling pathway drives spontaneous and …

Cancer immunotherapy has gained attention as the supreme therapeutic modality for the
treatment of various malignancies. Adoptive T-cell therapy (ACT) is one of the most …

Simple Summary Interferons are cytokines that play key roles in the activation of cellular
components of the immune response, such as dendritic cells, macrophages and T cells …

Here, we investigate the contribution of long-term hematopoietic stem cells (HSCs LT) to
trained immunity (TI) in the setting of chronic autoimmune disease. Using a mouse model of …

Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …

Effective T cell responses against infections and tumors require a swift and ample
production of cytokines, chemokines, and cytotoxic molecules. The production of these …

Optimal T cell activation requires Ag recognition through the TCR, engagement of
costimulatory molecules, and cytokines. T cells can also directly recognize danger signals …

CD8+ T cells kill target cells by releasing cytotoxic molecules and proinflammatory
cytokines, such as TNF and IFN‐γ. The magnitude and duration of cytokine production are …