LC-MS application for therapeutic drug monitoring in alternative matrices

V Avataneo, A D'Avolio, J Cusato, M Cantù… - … of pharmaceutical and …, 2019 - Elsevier
Nowadays the practice of therapeutic drug monitoring, consisting in the measurement of
drugs concentrations in biological matrices in order to guide possible posological …

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management

RJ Ellis, MJ Marquine, M Kaul, JA Fields… - Nature Reviews …, 2023 - nature.com
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Lentiviral infections persist in brain despite effective antiretroviral therapy and neuroimmune activation

N Mohammadzadeh, W Roda, WG Branton, J Clain… - MBio, 2021 - Am Soc Microbiol
ABSTRACT HIV infection persists in different tissue reservoirs among people with HIV
(PWH) despite effective antiretroviral therapy (ART). In the brain, lentiviruses replicate …

The effects of opioids on HIV neuropathogenesis

A Murphy, J Barbaro, P Martínez-Aguado… - Frontiers in …, 2019 - frontiersin.org
HIV associated neurocognitive disorders (HAND) are a group of neurological deficits that
affect approximately half of people living with HIV (PLWH) despite effective antiretroviral …

HIV-1-associated inflammation and antiretroviral therapy regulate astrocyte endoplasmic reticulum stress responses

S Nooka, A Ghorpade - Cell death discovery, 2017 - nature.com
Abstract Antiretroviral (ARV) therapy (ART) has effectively suppressed the incidence of
human immunodeficiency virus (HIV)-associated dementia in HIV-1 positive individuals …

[HTML][HTML] Retroviral elements in pathophysiology and as therapeutic targets for amyotrophic lateral sclerosis

W Li, D Pandya, N Pasternack, M Garcia-Montojo… - …, 2022 - Elsevier
The study of the role of retroviruses in amyotrophic lateral sclerosis (ALS) dates back to the
1960s shortly after transposable elements themselves were first discovered. It was quickly …

In vitro effect of antiretroviral drugs on cultured primary astrocytes: analysis of neurotoxicity and matrix metalloproteinase inhibition

T Latronico, I Pati, R Ciavarella… - Journal of …, 2018 - Wiley Online Library
There is little information available on the possible toxic effects that antiretroviral (ARV)
drugs used for the treatment of human immunodeficiency virus (HIV)‐infected subjects, may …

Permeation challenges of drugs for treatment of neurological tuberculosis and hiv and the application of magneto-electric nanoparticle drug delivery systems

S Mhambi, D Fisher, MBT Tchokonte, A Dube - Pharmaceutics, 2021 - mdpi.com
The anatomical structure of the brain at the blood–brain barrier (BBB) creates a limitation for
the movement of drugs into the central nervous system (CNS). Drug delivery facilitated by …

An update on drug–drug interactions between antiretroviral therapies and drugs of abuse in HIV systems

N Desai, L Burns, Y Gong, K Zhi, A Kumar… - Expert opinion on …, 2020 - Taylor & Francis
Introduction While considerable progress has been made in the fight against HIV/AIDS, to
date there has not been a cure, and millions of people around the world are currently living …

The role of pharmacomicrobiomics in HIV prevention, treatment, and women's health

EC Swanson, CM Basting, NR Klatt - Microbiome, 2024 - Springer
In the absence of an effective vaccine or curative treatment for HIV, the global HIV/AIDS
epidemic continues despite significant advances in treatment and prevention. Antiretroviral …