In our modern 'omics era, metabolic flux analysis (fluxomics) represents the physiological
counterpart of its siblings transcriptomics, proteomics and metabolomics. Fluxomics …

Rational engineering of metabolism is important for bio-production using microorganisms.
Metabolic design based on in silico simulations and experimental validation of the metabolic …

INTRODUCTION The generation of biological data is presenting us with one of the most
demanding analysis challenges the world has ever faced, not only in terms of storage and …

Engineering cellular metabolism for improved production of valuable chemicals requires
extensive modulation of bacterial genome to explore complex genetic spaces. Here, we …

Itaconic acid is a high potential platform chemical which is currently industrially produced by
Aspergillus terreus. Heterologous production of itaconic acid with Escherichia coli could …

Synthetic methylotrophy aims to develop non-native methylotrophic microorganisms to
utilize methane or methanol to produce chemicals and biofuels. We report two …

Metabolic flux analysis (MFA) quantitatively describes cellular fluxes to understand
metabolic phenotypes and functional behaviour after environmental and/or genetic …

Abstract Background Riboflavin (vitamin B 2), the precursor of the flavin cofactors flavin
mononucleotide (FMN) and flavin adenine dinucleotide (FAD), is used commercially as an …

Hyaluronic acid is a glycosaminoglycan biopolymer widely present throughout connective
and epithelial tissue, and has been of great interest for medical and cosmetic applications. In …

Unraveling the mechanisms of microbial adaptive evolution following genetic or
environmental challenges is of fundamental interest in biological science and engineering …