Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals
Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of
ancestry segments (local ancestry) originating from multiple continental ancestral …
ancestry segments (local ancestry) originating from multiple continental ancestral …
Genetic heterogeneity: Challenges, impacts, and methods through an associative lens
AA Woodward, RJ Urbanowicz, AC Naj… - Genetic …, 2022 - Wiley Online Library
Genetic heterogeneity describes the occurrence of the same or similar phenotypes through
different genetic mechanisms in different individuals. Robustly characterizing and …
different genetic mechanisms in different individuals. Robustly characterizing and …
[HTML][HTML] Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
J Lake, C Warly Solsberg, JJ Kim, J Acosta-Uribe… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …
out in European ancestry individuals despite the known variation in genetic architecture and …
Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals
Individuals of admixed ancestries (eg, African Americans) inherit a mosaic of ancestry
segments (local ancestry) originating from multiple continental ancestral populations. Their …
segments (local ancestry) originating from multiple continental ancestral populations. Their …
[HTML][HTML] Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape
Q Li, J Chen, P Faux, ME Delgado, B Bonfante… - Communications …, 2023 - nature.com
We report a genome-wide association study of facial features in> 6000 Latin Americans
based on automatic landmarking of 2D portraits and testing for association with inter …
based on automatic landmarking of 2D portraits and testing for association with inter …
[HTML][HTML] Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program
Abstract Background The Million Veteran Program (MVP) participants represent 100 years of
US history, including significant social and demographic changes over time. Our study …
US history, including significant social and demographic changes over time. Our study …
[PDF][PDF] Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations
Admixed populations, with their unique and diverse genetic backgrounds, are often
underrepresented in genetic studies. This oversight not only limits our understanding but …
underrepresented in genetic studies. This oversight not only limits our understanding but …
The Role of Global and Local Ancestry on Clopidogrel Response in African Americans
Pharmacogenomics has long lacked dedicated studies in African Americans, resulting in a
lack of indepth data in this populations. The ACCOuNT consortium has collected a cohort of …
lack of indepth data in this populations. The ACCOuNT consortium has collected a cohort of …
[HTML][HTML] Improved multi-ancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk
Multi-ancestry statistical fine-mapping of cis-molecular quantitative trait loci (cis-molQTL)
aims to improve the precision of distinguishing causal cis-molQTLs from tagging variants …
aims to improve the precision of distinguishing causal cis-molQTLs from tagging variants …
Single locus theory of admixture is insufficient for the study of complex traits in admixed populations
Admixed populations offer valuable insights into the genetic architecture of complex traits.
Such an investigation demands a delicate theory that can handle the linkage disequilibrium …
Such an investigation demands a delicate theory that can handle the linkage disequilibrium …