[HTML][HTML] Surviving reactive chlorine stress: responses of gram-negative bacteria to hypochlorous acid

WS da Cruz Nizer, V Inkovskiy, J Overhage - Microorganisms, 2020 - mdpi.com
Sodium hypochlorite (NaOCl) and its active ingredient, hypochlorous acid (HOCl), are the
most commonly used chlorine-based disinfectants. HOCl is a fast-acting and potent …

[HTML][HTML] Thiol-based redox switches in prokaryotes

M Hillion, H Antelmann - Biological chemistry, 2015 - degruyter.com
Bacteria encounter reactive oxygen species (ROS) as a consequence of the aerobic life or
as an oxidative burst of activated neutrophils during infections. In addition, bacteria are …

The physiological role of reversible methionine oxidation

A Drazic, J Winter - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2014 - Elsevier
Sulfur-containing amino acids such as cysteine and methionine are particularly vulnerable
to oxidation. Oxidation of cysteine and methionine in their free amino acid form renders them …

Characterization of water treatment-resistant and multidrug-resistant urinary pathogenic Escherichia coli in treated wastewater

S Zhi, P Stothard, G Banting, C Scott, K Huntley, K Ryu… - Water research, 2020 - Elsevier
A growing body of evidence has demonstrated that extraintestinal pathogenic E. coli
(ExPEC), such as the urinary pathogenic E. coli (UPEC), are common constituents of treated …

The locus of heat resistance confers resistance to chlorine and other oxidizing chemicals in Escherichia coli

Z Wang, Y Fang, S Zhi, DJ Simpson, A Gill… - Applied and …, 2020 - Am Soc Microbiol
Some chlorine-resistant Escherichia coli isolates harbor the locus of heat resistance (LHR),
a genomic island conferring heat resistance. In this study, the protective effect of the LHR for …

Oxidation of phosphorothioate DNA modifications leads to lethal genomic instability

S Kellner, MS DeMott, CP Cheng, BS Russell… - Nature chemical …, 2017 - nature.com
Genomic modification by sulfur in the form of phosphorothioate (PT) is widespread among
prokaryotes, including human pathogens. Apart from its physiological functions, PT sulfur …

[HTML][HTML] CnoX is a chaperedoxin: a holdase that protects its substrates from irreversible oxidation

CV Goemans, D Vertommen, R Agrebi, JF Collet - Molecular cell, 2018 - cell.com
Bleach (HOCl) is a powerful oxidant that kills bacteria in part by causing protein aggregation.
It inactivates ATP-dependent chaperones, rendering cellular proteins mostly dependent on …

In situ synthesis of gold nanoclusters in hydrogels for the capillary based portable fluorescence analysis of hypochlorite in environmental samples

CZ Peng, H Zhang, N Pi, X Li, Q Yang… - Environmental …, 2023 - pubs.rsc.org
Bovine serum albumin (BSA) reduced HAuCl4 under alkaline conditions to achieve the
rapid in situ growth of gold nanoclusters (Au NCs) in hydrogels. The hydrogels doped with …

[HTML][HTML] Redox regulation in host-pathogen interactions: thiol switches and beyond

M Varatnitskaya, A Degrossoli, LI Leichert - Biological Chemistry, 2021 - degruyter.com
Our organism is exposed to pathogens on a daily basis. Owing to this age-old interaction,
both pathogen and host evolved strategies to cope with these encounters. Here, we focus on …

The redox-sensing mechanism of Agrobacterium tumefaciens NieR as a thiol-based oxidation sensor for hypochlorite stress

B Nontaleerak, C Eurtivong, C Weeraphan… - Free Radical Biology …, 2023 - Elsevier
NieR is a TetR family transcriptional repressor previously shown to regulate the NaOCl-
inducible efflux pump NieAB in Agrobacterium tumefaciens. NieR is an ortholog of …