[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

FGF23 and its role in X-linked hypophosphatemia-related morbidity

SS Beck-Nielsen, Z Mughal, D Haffner… - Orphanet Journal of …, 2019 - Springer
Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate
metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase …

Insulin suppresses the production of fibroblast growth factor 23 (FGF23)

L Bär, M Feger, A Fajol, LO Klotz… - Proceedings of the …, 2018 - National Acad Sciences
Fibroblast growth factor 23 (FGF23) is produced by bone cells and regulates renal
phosphate and vitamin D metabolism, as well as causing left ventricular hypertrophy. FGF23 …

The crosstalk between pattern-recognition receptor signaling and calcium signaling

F Kong, H You, K Zheng, R Tang, C Zheng - International Journal of …, 2021 - Elsevier
The innate immune system is the first line of host defense, and it is capable of resisting both
exogenous pathogenic challenges and endogenous danger signals via different pattern …

The regulation of FGF23 under physiological and pathophysiological conditions

S Rausch, M Föller - Pflügers Archiv-European Journal of Physiology, 2022 - Springer
Abstract Fibroblast growth factor 23 (FGF23) is an important bone hormone that regulates
phosphate homeostasis in the kidney along with active vitamin D (1, 25 (OH) 2D3) and …

Osteocytic FGF23 and its kidney function

R Agoro, P Ni, ML Noonan, KE White - Frontiers in endocrinology, 2020 - frontiersin.org
Osteocytes, which represent up to 95% of adult skeletal cells, are deeply embedded in bone.
These cells exhibit important interactive abilities with other bone cells such as osteoblasts …

Regulation of fibroblast growth factor 23 (FGF 23) in health and disease

L Bär, C Stournaras, F Lang, M Föller - FEBS letters, 2019 - Wiley Online Library
Fibroblast growth factor 23 (FGF 23) is mainly produced in the bone and, upon secretion,
forms a complex with a FGF receptor and coreceptor αKlotho. FGF 23 can exert several …

Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and men

A Daryadel, C Bettoni, T Haider… - … -European Journal of …, 2018 - Springer
Abstract Fibroblast growth factor 23 (FGF23) is a major endocrine regulator of phosphate
and 1, 25 (OH) 2 vitamin D 3 metabolism and is mainly produced by osteocytes. Its …

[HTML][HTML] Phosphate homeostasis, inflammation and the regulation of FGF-23

F Lang, C Leibrock, AA Pandyra… - Kidney and Blood …, 2018 - karger.com
Abstract Fibroblast growth factor 23 (FGF23) is released primarily from
osteoblasts/osteocytes in bone. In cooperation with the transmembrane protein Klotho …

Up-regulation of FGF23 release by aldosterone

B Zhang, AT Umbach, H Chen, J Yan, H Fakhri… - Biochemical and …, 2016 - Elsevier
The fibroblast growth factor (FGF23) plasma level is high in cardiac and renal failure and is
associated with poor clinical prognosis of these disorders. Both diseases are paralleled by …