Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …

T cell responses must be balanced to ensure adequate protection against malignant
transformation and an array of pathogens while also limiting damage to healthy cells and …

Recent advances in immunotherapy have affirmed the curative potential of T cell-based
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …

Thirty years of foundational research investigating molecular and cellular mechanisms
promoting T cell exhaustion are now enabling rational design of T cell–based therapies for …

Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in
transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can …

Highly coordinated changes in gene expression underlie T cell activation and exhaustion.
However, the mechanisms by which such programs are regulated and how these may be …

Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of
hematological malignancies. Manufacturing of these cellular products includes culture …

In the past decade, the emergence of chimeric antigen receptor (CAR) T-cell therapy has led
to a cellular immunotherapy revolution against various cancers. Although CAR-T cell …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

The functional state of chimeric antigen receptor T (CAR T) cells determines their efficacy in
vivo. Exhausted CAR T cells exhibit decreased proliferative capacity, impaired anti-tumor …