Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis
TS Kang, D Georgieva, N Genov… - The FEBS …, 2011 - Wiley Online Library
Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the
immobilization and digestion of prey. The most common snake venom enzymes include …
immobilization and digestion of prey. The most common snake venom enzymes include …
Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis
L Chioato, RJ Ward - Toxicon, 2003 - Elsevier
In addition to their catalytic activity, snake venom phospholipases A2 (vPLA2) present
remarkable diversity in their biological effects. Sequence alignment analyses of functionally …
remarkable diversity in their biological effects. Sequence alignment analyses of functionally …
First structural evidence of a specific inhibition of phospholipase A2 by α-tocopherol (vitamin E) and its implications in inflammation: Crystal structure of the complex …
This is the first structural evidence of α-tocopherol (α-TP) as a possible candidate against
inflammation, as it inhibits phospholipase A2 specifically and effectively. The crystal …
inflammation, as it inhibits phospholipase A2 specifically and effectively. The crystal …
Structural Basis of Phospholipase A2 Inhibition for the Synthesis of Prostaglandins by the Plant Alkaloid Aristolochic Acid from a 1.7 Å Crystal Structure,
This is the first structural observation of a plant product showing high affinity for
phospholipase A2 and regulating the synthesis of arachidonic acid, an intermediate in the …
phospholipase A2 and regulating the synthesis of arachidonic acid, an intermediate in the …
Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular …
Background The snake venom group IIA secreted phospholipases A 2 (SVPLA 2), present in
the Viperidae snake family exhibit a wide range of toxic and pharmacological effects. They …
the Viperidae snake family exhibit a wide range of toxic and pharmacological effects. They …
[HTML][HTML] Active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory phospholipase A2 through …
T Vinuchakkaravarthy, KP Kumaravel… - …, 2011 - ncbi.nlm.nih.gov
Novel compounds with significant medicinal properties have gained much interest in
therapeutic approaches for treating various inflammatory disorders like arthritis, odema and …
therapeutic approaches for treating various inflammatory disorders like arthritis, odema and …
[HTML][HTML] Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca2+-binding loop region for the catalytically inactive …
CAH Fernandes, DP Marchi-Salvador… - Journal of structural …, 2010 - Elsevier
Phospholipases A2 (Asp49-PLA2s) are enzymes responsible for cellular membrane
disruption through Ca2+-dependent hydrolysis of phospholipids. A class of these proteins …
disruption through Ca2+-dependent hydrolysis of phospholipids. A class of these proteins …
Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A2 class
JI dos Santos, M Cintra‐Francischinelli… - Proteins: Structure …, 2011 - Wiley Online Library
Abstract Phospholipases A2 (PLA2s) are enzymes responsible for membrane disruption
through Ca2+‐dependent hydrolysis of phospholipids. Lys49‐PLA2s are well‐characterized …
through Ca2+‐dependent hydrolysis of phospholipids. Lys49‐PLA2s are well‐characterized …
Structures and binding studies of the complexes of phospholipase A2 with five inhibitors
Abstract Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids into
arachidonic acid and lysophospholipids. Arachidonic acid is used as a substrate in the next …
arachidonic acid and lysophospholipids. Arachidonic acid is used as a substrate in the next …
Identification of a novel and potent inhibitor of phospholipase A2 in a medicinal plant: crystal structure at 1.93 Å and Surface Plasmon Resonance analysis of …
DN Chandra, GK Prasanth, N Singh, S Kumar… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Crystal of Russell Viper venom phospholipase A2 complexed with an isoquinoline alkaloid,
berberine from a herbaceous plant Cardiospermum halicacabum, was prepared and its …
berberine from a herbaceous plant Cardiospermum halicacabum, was prepared and its …