Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

A myriad of pathological changes associated with epilepsy can be recast as decreases in
cell and circuit heterogeneity. We thus propose recontextualizing epileptogenesis as a …

Accumulating evidence indicates that there are substantial species differences in the
properties of mammalian neurons, yet theories on circuit activity and information processing …

The interplay between neuronal structure and function underpins the dynamic nature of
neocortical networks. Despite extensive studies in animal models, our understanding of …

Background Whole-cell patch-clamp electrophysiology is an essential technique for
understanding how single neurons translate their diverse inputs into a functional output. The …

Reduced inhibition by somatostatin-expressing interneurons is associated with depression.
Administration of positive allosteric modulators of α5 subunit-containing GABAA receptor (α5 …

The basic excitatory neurons of the cerebral cortex, the pyramidal cells, are the most
important signal integrators for the local circuit. They have quite characteristic morphological …

Treatment for major depressive disorder (depression) often has partial efficacy and a large
portion of patients are treatment resistant. Recent studies implicate reduced somatostatin …

Discerning the contribution of specific ionic currents to complex neuronal dynamics is a
difficult, but important, task. This challenge is exacerbated in the human setting, although the …

Computation within cortical microcircuits is determined by functional properties of the
neurons and their synaptic interactions. While heterogeneity of inhibitory interneurons is well …