All proteins in mammalian cells are continually being degraded and replaced. In the cytosol,
nucleus, and organelles, individual proteins are degraded at widely differing rates; some …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other
systemic diseases that results primarily from accelerated protein degradation by the …

Increased Protein Intake Reduces Lean Body Mass Loss during Weight Loss in Athletes
Page 1 by the American College of Sports Medicine. Unauthorized reproduction of this …

Loss of myofibrillar proteins is a hallmark of atrophying muscle. Expression of muscle RING-
finger 1 (MuRF1), a ubiquitin ligase, is markedly induced during atrophy, and MuRF1 …

All intracellular proteins and many extracellular proteins are continually “turning over”; ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

We previously identified a common set of genes, termed atrogenes, whose expression is
coordinately induced or suppressed in muscle during systemic wasting states (fasting …

Muscle atrophy results primarily from accelerated protein degradation and is associated with
increased expression of two muscle-specific ubiquitin ligases (E3s): atrogin-1 and muscle …

Sarcopenia, loss of muscle mass and function, is a common feature of aging. Oxidative
damage and apoptosis are likely underlying factors. Autophagy, a process for the …