The importance of protecting brain function for people with sickle cell disease (SCD) cannot
be overstated. SCD is associated with multiple cerebrovascular complications that threaten …

This review summarizes the current evidence in systematic reviews, meta-analysis and
randomized controlled trials regarding adenotonsillectomy outcomes in pediatric obstructive …

Pediatric patients with sickle cell disease (SCD) experience a range of medical
complications that result in significant morbidity and mortality. Recent advances in …

Sickle cell disease (SCD) encompasses an inherited group of disorders with the presence of
hemoglobin S (HbS) as a homozygous mutation (HbSS) or compound heterozygosity with …

Background Sickle cell disease (SCD) is a genetic hemoglobinopathy with an incidence of
250–300,000 births per year worldwide. SCD leads to a diffuse vasculopathy which …

Obstructive sleep apnea (OSA) is common in sickle cell disease (SCD) despite the absence
of overweight, suggesting a specific pathophysiology. We previously showed that otherwise …

Background Pain and sleep disturbances are prevalent complications experienced by
pediatric patients with sickle cell disease (SCD). This study aims to identify associations …

Though endogenous S‐nitroso‐l‐cysteine (l‐CSNO) signaling at the level of the carotid
body increases minute ventilation (v̇E), neither the background data nor the potential …

Youth living with sickle cell disease (SCD) often face neurocognitive challenges, regardless
of accompanying neurological issues. While screening and intervention advancements have …

Based on the presenting symptoms, you should deduce that the most likely diagnosis for
your patient is comorbid OSA and insomnia. OSA is the most common sleep-disordered …