Phase transitions of associative biomacromolecules
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …
biomacromolecules, provide the driving forces for the formation and compositional …
The molecular basis for cellular function of intrinsically disordered protein regions
AS Holehouse, BB Kragelund - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains
Prion-like low-complexity domains (PLCDs) have distinctive sequence grammars that
determine their driving forces for phase separation. Here we uncover the physicochemical …
determine their driving forces for phase separation. Here we uncover the physicochemical …
Physical principles underlying the complex biology of intracellular phase transitions
JM Choi, AS Holehouse… - Annual review of …, 2020 - annualreviews.org
Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …
have the hallmarks of intracellular phase transitions. This suggests that a common …
Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.
EW Martin, AS Holehouse - Emerging topics in life sciences, 2020 - europepmc.org
Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …
Molecular and environmental determinants of biomolecular condensate formation
JA Villegas, M Heidenreich, ED Levy - Nature chemical biology, 2022 - nature.com
Biomolecular condensate formation has been implicated in a host of biological processes
and has found relevance in biology and disease. Understanding the physical principles and …
and has found relevance in biology and disease. Understanding the physical principles and …
Expanding the molecular language of protein liquid–liquid phase separation
Understanding the relationship between a polypeptide sequence and its phase separation
has important implications for analysing cellular function, treating disease and designing …
has important implications for analysing cellular function, treating disease and designing …
Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior
Phase separation of intrinsically disordered proteins (IDPs) commonly underlies the
formation of membraneless organelles, which compartmentalize molecules intracellularly in …
formation of membraneless organelles, which compartmentalize molecules intracellularly in …
Ligand effects on phase separation of multivalent macromolecules
Biomolecular condensates enable spatial and temporal control over cellular processes by
concentrating biomolecules into nonstoichiometric assemblies. Many condensates form via …
concentrating biomolecules into nonstoichiometric assemblies. Many condensates form via …
Clustering of aromatic residues in prion-like domains can tune the formation, state, and organization of biomolecular condensates: published as part of the …
In immature oocytes, Balbiani bodies are conserved membraneless condensates implicated
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …
in oocyte polarization, the organization of mitochondria, and long-term organelle and RNA …