While the benefits of physical exercise for a healthy aging are well-recognized, a growing
body of evidence shows that sedentary behavior has deleterious health effects …

Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …

Background: Maintaining skeletal muscle mass and function in aging is crucial for
preserving the quality of life and health. An experimental bed rest (BR) protocol is a suitable …

Both regular exercise training and beta-hydroxy-beta-methylbutyrate (HMB)
supplementation are shown as effective treatments to delay or reverse frailty and reduce …

Background Older adults exposed to periods of inactivity during hospitalization, illness, or
injury lose muscle mass and strength. This, in turn, predisposes poor recovery of physical …

Methods: Studies were performed in ethanol-treated differentiated C2C12 myotubes and
physiological relevance established in an ethanol-fed mouse model of alcohol-related liver …

Preserving skeletal muscle mass and functional capacity is essential for healthy ageing.
Transient periods of disuse and/or inactivity in combination with sub-optimal dietary intake …

Skeletal muscle atrophy is a clinically important outcome of disuse because of injury,
immobilization, or bed rest. Disuse atrophy is accompanied by mitochondrial dysfunction …

Impaired muscle recovery (size and strength) following a disuse period commonly occurs in
older adults. Many of these individuals are not able to adequately exercise due to pain and …

With extended life expectancy, the older population is constantly increasing, and
consequently, so too is the prevalence of age-related disorders. Sarcopenia, the …