Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens
Aiton. At present, a large number of studies have proved that matrine has an anticancer …

Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen),
Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives …

Previous studies have shown that the main function of VASP is to regulate the cytoskeleton
and play an important role in promoting tumor cell metastasis. In this study, we first reveal …

Background Gastric cancer (GC) ranks as the fifth most prevalent malignancy worldwide.
Conventional treatments, including radiotherapy and chemotherapy, often induce severe …

Gastric cancer belongs to the heterogeneous malignancies and, according to the World
Health Organization, it is the fifth most commonly diagnosed cancer in men. The aim of this …

BRAF is frequently mutated in various cancer types and contributes to tumorigenesis and
metastasis. As an important switch in RAS signaling pathway, BRAF typically enables the …

Berberine is a plant-derived compound used in traditional Chinese medicine, which has
been shown to inhibit cell proliferation and migration in breast cancer. On the other hand …

After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an
inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as …

Comprehensively understanding pharmacological functions of natural products is a key
issue to be addressed for the discovery of new drugs. Unlike some single-target drugs …

The aim of the present study was to investigate the effect of matrine on breast cancer and its
underlying mechanism. Matrine is a major component of Sophora flavescens, exhibited …