Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation

M Kropp, O Golubnitschaja, A Mazurakova… - Epma Journal, 2023 - Springer
Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent
complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age …

Update in the epidemiology, risk factors, screening, and treatment of diabetic retinopathy

KY Lin, WH Hsih, YB Lin, CY Wen… - Journal of diabetes …, 2021 - Wiley Online Library
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and
is the leading cause of visual loss in the elderly. Hyperglycemia and altered metabolic …

Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

L Koklesova, A Mazurakova, M Samec, K Biringer… - EPMA Journal, 2021 - Springer
Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …

Diagnostic, prognostic, and mechanistic biomarkers of diabetes mellitus-associated cognitive decline

H Ehtewish, A Arredouani, O El-Agnaf - International journal of molecular …, 2022 - mdpi.com
Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …

Homocysteine induces inflammation in retina and brain

NM Elsherbiny, I Sharma, D Kira, S Alhusban… - Biomolecules, 2020 - mdpi.com
Homocysteine (Hcy) is an amino acid that requires vitamins B12 and folic acid for its
metabolism. Vitamins B12 and folic acid deficiencies lead to hyperhomocysteinemia (HHcy …

Aiding the diagnosis of diabetic and hypertensive retinopathy using artificial intelligence-based semantic segmentation

M Arsalan, M Owais, T Mahmood, SW Cho… - Journal of clinical …, 2019 - mdpi.com
Automatic segmentation of retinal images is an important task in computer-assisted medical
image analysis for the diagnosis of diseases such as hypertension, diabetic and …

Early biomarkers of neurodegenerative and neurovascular disorders in diabetes

A Gasecka, D Siwik, M Gajewska… - Journal of Clinical …, 2020 - mdpi.com
Diabetes mellitus (DM) is a common disease worldwide. There is a strong association
between DM and neurovascular and neurodegenerative disorders. The first group mainly …

KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy

Y Qi, R Yao, W Zhang, Q Cui - Pharmacological Research, 2021 - Elsevier
Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of
blindness and visual impairment. This study focuses on the function of lysine …

Implication of hyperhomocysteinemia in blood retinal barrier (BRB) dysfunction

A Tawfik, YA Samra, NM Elsherbiny, M Al-Shabrawey - Biomolecules, 2020 - mdpi.com
Elevated plasma homocysteine (Hcy) level, known as hyperhomocysteinemia (HHcy) has
been linked to different systemic and neurological diseases, well-known as a risk factor for …

Folate and retinal vascular diseases

J Gu, C Lei, M Zhang - BMC ophthalmology, 2023 - Springer
Folate, a pteroylglutamic acid derivative, participates in fundamental cellular metabolism.
Homocysteine, an amino acid, serves as an intermediate of the methionine cycle and can be …