Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance
Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
(H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
[HTML][HTML] Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways
U Seroussi, C Li, AE Sundby, TL Lee… - Seminars in Cell & …, 2022 - Elsevier
RNA interference (RNAi) is a highly conserved gene regulatory phenomenon whereby
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
Argonaute/small RNA (AGO/sRNA) complexes target transcripts by antisense …
H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity
SP Methot, J Padeken, G Brancati, P Zeller… - Nature cell …, 2021 - nature.com
The developmental role of histone H3K9 methylation (H3K9me), which typifies
heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a …
heterochromatin, remains unclear. In Caenorhabditis elegans, loss of H3K9me leads to a …
SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity
CE Delaney, SP Methot, V Kalck, J Seebacher… - Nature structural & …, 2022 - nature.com
Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9
(H3K9me) is critical for maintaining organismal viability and tissue integrity. Here we show …
(H3K9me) is critical for maintaining organismal viability and tissue integrity. Here we show …
H3K9me1/2 methylation limits the lifespan of daf-2 mutants in C. elegans
Histone methylation plays crucial roles in the development, gene regulation, and
maintenance of stem cell pluripotency in mammals. Recent work shows that histone …
maintenance of stem cell pluripotency in mammals. Recent work shows that histone …
XOL-1 regulates developmental timing by modulating the H3K9 landscape in C. elegans early embryos
Sex determination in the nematode C. elegans is controlled by the master regulator XOL-1
during embryogenesis. Expression of xol-1 is dependent on the ratio of X chromosomes and …
during embryogenesis. Expression of xol-1 is dependent on the ratio of X chromosomes and …
Chromosome organization in 4D: insights from C. elegans development
Eukaryotic genome organization is ordered and multilayered, from the nucleosome to
chromosomal scales. These layers are not static during development, but are remodeled …
chromosomal scales. These layers are not static during development, but are remodeled …
Differentially expressed genes associated with body size changes and transposable element insertions between Caenorhabditis elegans and its sister species …
K Kawahara, T Inada, R Tanaka, M Dayi… - Genome Biology and …, 2023 - academic.oup.com
Why the recently discovered nematode Caenorhabditis inopinata differs so greatly from its
sibling species Caenorhabditis elegans remains unknown. A previous study showed that C …
sibling species Caenorhabditis elegans remains unknown. A previous study showed that C …
A transcriptional cofactor regulatory network for the C. elegans intestine
BB Horowitz, S Nanda… - G3: Genes, Genomes …, 2023 - academic.oup.com
Chromatin modifiers and transcriptional cofactors (collectively referred to as CFs) work with
DNA-binding transcription factors (TFs) to regulate gene expression. In multicellular …
DNA-binding transcription factors (TFs) to regulate gene expression. In multicellular …
The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease
H Luo, X Wu, XH Zhu, X Yi, D Du, DS Jiang - Epigenetics & Chromatin, 2023 - Springer
Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine
methyltransferase 1, also known as ESET or KMT1E) is known to be involved in the …
methyltransferase 1, also known as ESET or KMT1E) is known to be involved in the …