The liver metabolizes ethanol through three enzymatic pathways: alcohol dehydrogenase
(ADH), cytochrome p450 (also called MEOS), and catalase. Alcohol dehydrogenase class I …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Septic acute liver injury is one of the leading causes of fatalities in patients with sepsis. Toll-
like receptor 4 (TLR4) plays a vital role in response to lipopolysaccharide (LPS) challenge …

Chronic alcohol abuse causes liver disease that progresses from simple steatosis through
stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic failure. In addition …

Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol
consumption is beneficial to cardiovascular health, heavy drinking often results in organ …

Alcoholic cardiomyopathy is manifested as cardiac hypertrophy, disrupted contractile
function and myofibrillary architecture. An ample amount of clinical and experimental …

Liver cancer is the second most frequent cause of cancer-related death globally. The main
histological subtype is hepatocellular carcinoma (HCC), which is derived from hepatocytes …

Human birth defects are highly variable and this phenotypic variability can be influenced by
both the environment and genetics. However, the synergistic interactions between these two …

This study aimed to elucidate the anti-inflammatory, anti-oxidant and antifibrotic effects of
gold nanoparticles (GNPs) in rats subjected to liver injury with ethanol and …

Background We have previously demonstrated that Lactobacillus rhamnosus GG culture
supernatant (LGGs) prevents acute-alcohol-exposure-induced hepatic steatosis and injury …