This article presents a short discussion of the development of the human genome program
in the United States, a summary of the current status of the organization and administration …

Sequence similarity between a translated nucleotide sequence and a known biological
protein can provide strong evidence for the presence of a homologous coding region, even …

Von Recklinghausen neurofibromatosis (NF1) is a common autosomal dominant disorder
characterized by abnormalities in multiple tissues derived from the neural crest. No reliable …

Ten years after the Human Genome Project's completion the life sciences stand in a moment
of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in …

Mutual information function, which is an alternative to correlation function for symbolic
sequences, and a" symbolic spectrum" are calculated for a human DNA sequence …

Two issues in the evolution of the intron/exon structure of genes are the role of exon
shuffling and the origin of introns. Using a large data base of eukaryotic intron-containing …

A database of 209 Drosophila Introns was extracted from Genbank (release number 64.0)
and examined by a number of methods in order to characterize features that might serve as …

In this paper, statistical methods based on a hidden Markov chain model are used to study
the structure of some small complete genomes and a human genome segment. A variety of …

ABSTRACT A computer program called BLASTX was previously shown to be effective in
identifying and assigning putative function to likely protein coding regions by detecting …

If genes have been assembled from exon subunits, the frequency with which exons are
reused leads to an estimate of the size of the underlying exon universe. An exon database …