Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most
abundant non-protein thiol that defends against oxidative stress. GSH is also a key …

Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

The expression of genes encoding antioxidative and Phase II detoxification enzymes is
induced in cells exposed to electrophilic compounds and phenolic antioxidants. Induction of …

Coordinated regulation of the ubiquitin-proteasome system (UPS) is crucial for the cell to
adjust its protein degradation capacity to changing proteolytic requirements. We have shown …

Fruits and vegetables protect against cancer by so far not well-characterized mechanisms.
One likely explanation for this effect is that dietary plants contain substances able to control …

Transactivation of phase II detoxification enzymes and antioxidant proteins is mediated by
the Cap'N′ Collar transcription factor, Nrf2, which is sequestered in the cytoplasm by the …

Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition.
Recently, potential health benefits of astaxanthin have been discussed which may be partly …

Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells.
It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and …

This article provides an overview of the mechanisms by which cancer chemopreventive
blocking agents increase the expression of detoxication and antioxidant genes. These …