Cell-Mediated Immunological Biomarkers and Their Diagnostic Application in Livestock and Wildlife Infected With Mycobacterium bovis

K Smith, L Kleynhans, RM Warren, WJ Goosen… - Frontiers in …, 2021 - frontiersin.org
Mycobacterium bovis has the largest host range of the Mycobacterium tuberculosis complex
and infects domestic animal species, wildlife, and humans. The presence of global wildlife …

[HTML][HTML] Revisiting tuberculosis screening: An insight to complementary diagnosis and prospective molecular approaches for the recognition of the dormant TB …

AH Alvarez - Microbiological Research, 2021 - Elsevier
Tuberculosis (TB) is defined as a chronic infection in both human and cattle hosts and many
subclinical cases remain undetected. After the pathogen is inhaled by a host, phagocyted …

Biomarkers of cell-mediated immunity to bovine tuberculosis

MV Palmer, TC Thacker, MM Rabideau… - Veterinary immunology …, 2020 - Elsevier
Whole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs),
are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the …

Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis

H Khalid, L Pierneef, A Van Hooij, Z Zhou… - Frontiers in Veterinary …, 2023 - frontiersin.org
Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis) infection in cattle, is
an economically devastating chronic disease for livestock worldwide. Efficient disease …

Identification of bovine tuberculosis biomarkers to detect tuberculin skin test and IFNγ release assay false negative cattle

LI Klepp, ME Eirin, S Garbaccio, M Soria, F Bigi… - Research in veterinary …, 2019 - Elsevier
Bovine tuberculosis (bTB) is an important animal and zoonotic disease, which causes
severe economic losses. The main focus of this study was to assess the predictive power of …

Interleukin 8 and pentaxin (C-reactive protein) as potential new biomarkers of bovine tuberculosis

X Gao, X Guo, M Li, H Jia, W Lin, L Fang… - Journal of clinical …, 2019 - Am Soc Microbiol
Bovine tuberculosis (bTB) is caused by Mycobacterium bovis. During the early stage of
infection, greater than 15% of M. bovis-infected cattle shed mycobacteria through nasal …

Simultaneous measurement of antigen-induced CXCL10 and IFN-γ enhances test sensitivity for bovine TB detection in cattle

M Coad, M Doyle, S Steinbach, E Gormley… - Veterinary …, 2019 - Elsevier
Bovine tuberculosis (BTB) is a disease of economic and zoonotic importance caused mainly
by Mycobacterium bovis. In addition to the tuberculin skin test, an interferon-gamma (IFN-γ) …

Parallel measurement of IFN-γ and IP-10 in QuantiFERON®-TB Gold (QFT) plasma improves the detection of Mycobacterium bovis infection in African buffaloes …

N Bernitz, TJ Kerr, WJ Goosen, C Clarke… - Preventive veterinary …, 2019 - Elsevier
Abstract The QuantiFERON®-TB Gold (QFT) stimulation platform for cytokine release is a
novel approach for diagnosis of bovine tuberculosis in wildlife species. Plasma interferon …

Elevated interferon-γ–induced protein 10 and its receptor CXCR3 impair NK cell function during HIV infection

Z Wang, T Wu, M Ma, Z Zhang, Y Fu… - Journal of Leukocyte …, 2017 - academic.oup.com
As the first line of defense in the human immune system, NK cells play essential roles in
prevention of tumorigenesis and viral infection. It is known that NK cells have impaired …

Biomarkers for detecting resilience against mycobacterial disease in animals

K Wright, K Plain, A Purdie, BM Saunders… - Infection and …, 2019 - Am Soc Microbiol
Paratuberculosis and bovine tuberculosis are two mycobacterial diseases of ruminants
which have a considerable impact on livestock health, welfare, and production. These are …