Pharmacological and neurosurgical management of cerebral palsy and dystonia: Clinical practice guideline update

D Fehlings, B Agnew, H Gimeno… - … Medicine & Child …, 2024 - Wiley Online Library
Dystonia, typically characterized by slow repetitive involuntary movements, stiff abnormal
postures, and hypertonia, is common among individuals with cerebral palsy (CP). Dystonia …

The development of cannabinoids as therapeutic agents in the United States

CH Murray, BM Gannon… - Pharmacological …, 2024 - pharmrev.aspetjournals.org
Cannabis is one of the oldest and widely used substances in the world. Cannabinoids within
the cannabis plant, known as phytocannabinoids, mediate cannabis' effects through …

[HTML][HTML] Nabiximols is efficient as add-on treatment for patients with multiple sclerosis spasticity refractory to standard treatment: a systematic review and meta-analysis …

D Kleiner, IL Horvath, S Bunduc, D Gergő… - Current …, 2023 - ncbi.nlm.nih.gov
Background Spasticity affects 54% of multiple sclerosis (MS) patients at disease onset, but
this rate gradually increases with disease progression. Spasticity does not fully respond to …

Efficacy and safety of nabiximols cannabinoid medicine for paediatric spasticity in cerebral palsy or traumatic brain injury: a randomized controlled trial

C Fairhurst, R Kumar, D Checketts… - … Medicine & Child …, 2020 - Wiley Online Library
Aim To assess the efficacy, safety, and tolerability of oromucosal nabiximols cannabinoid
medicine as adjunct therapy for children with spasticity due to cerebral palsy/traumatic …

Cannabinoids induce latent sensitization in a preclinical model of medication overuse headache

CM Kopruszinski, E Navratilova, B Vagnerova… - …, 2020 - journals.sagepub.com
Aim Evaluation of cannabinoid receptor agonists in a preclinical model of medication
overuse headache. Methods Female Sprague Dawley rats received graded intraperitoneal …

Cannabis and Cannabinoids in Multiple Sclerosis: From Experimental Models to Clinical Practice—A Review

CA Sirbu, R Georgescu, FC Pleşa… - American Journal of …, 2023 - journals.lww.com
Background: As far as 80% of people diagnosed with multiple sclerosis (MS) experience
disabling symptoms in the course of the disease, such as spasticity and neuropathic pain. As …

UK research priority setting for childhood neurological conditions

J Cadwgan, J Goodwin, B Babcock… - … Medicine & Child …, 2024 - Wiley Online Library
Aim To identify research priorities regarding the effectiveness of interventions for children
and young people (CYP) with childhood neurological conditions (CNCs). These include …

Clinical approaches to Cannabis: A narrative review

DE Slawek, SA Curtis, JH Arnsten… - Medical …, 2022 - medical.theclinics.com
Background In the late nineteenth and early twentieth centuries, cannabis in the United
States was mostly restricted to medical use, including for the management of pain …

Rehabilitation management: hypertonia

C Joseph, E Bailey-Sands, R Simenson… - Current Problems in …, 2023 - Elsevier
Many of us have a layman's understanding of spasticity as being stiff and tight, but the
clinical definition is much more complicated. We hear the terms low tone, high tone …

Cannabinoids: Potential for Modulation and Enhancement When Combined with Vitamin B12 in Case of Neurodegenerative Disorders

AA Kaszyńska - Pharmaceuticals, 2024 - mdpi.com
The enduring relationship between humanity and the cannabis plant has witnessed
significant transformations, particularly with the widespread legalization of medical …