The keratoconus enigma: a review with emphasis on pathogenesis

G Ferrari, P Rama - The ocular surface, 2020 - Elsevier
Purpose To review the literature on the etiopathogenesis of keratoconus (KC). Methods A
literature search was conducted using PUBMED and Google Scholar for keratoconus. The …

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

R Sharif, S Bak-Nielsen, J Hjortdal… - Progress in retinal and …, 2018 - Elsevier
Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that
include discomfort, visual disturbance and possible blindness if left untreated. KC affects …

Update on the genetics of keratoconus

Y Bykhovskaya, YS Rabinowitz - Experimental Eye Research, 2021 - Elsevier
In the past few years we have seen a great acceleration of discoveries in the field of
keratoconus including new treatments, diagnostic tools, genomic and molecular …

Big data in corneal diseases and cataract: Current applications and future directions

DSJ Ting, R Deshmukh, DSW Ting, M Ang - Frontiers in Big Data, 2023 - frontiersin.org
The accelerated growth in electronic health records (EHR), Internet-of-Things, mHealth,
telemedicine, and artificial intelligence (AI) in the recent years have significantly fuelled the …

Genetics in Keratoconus: where are we?

Y Bykhovskaya, B Margines, YS Rabinowitz - Eye and Vision, 2016 - Springer
Keratoconus (KC) is a non-inflammatory thinning and protrusion of the cornea in which the
cornea assumes a conical shape. Complex etiology of this condition at present remains an …

Genetic aspects of keratoconus: a literature review exploring potential genetic contributions and possible genetic relationships with comorbidities

E Loukovitis, K Sfakianakis, P Syrmakesi… - Ophthalmology and …, 2018 - Springer
Introduction Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial
degenerative disorder that is accompanied by corneal ectasia which usually progresses …

Genetic and environmental risk factors for keratoconus

SEM Lucas, KP Burdon - Annual Review of Vision Science, 2020 - annualreviews.org
Keratoconus, a progressive corneal ectasia, is a complex disease with both genetic and
environmental risk factors. The exact etiology is not known and is likely variable between …

Genetic associations for keratoconus: a systematic review and meta-analysis

SS Rong, STU Ma, XT Yu, L Ma, WK Chu, TCY Chan… - Scientific reports, 2017 - nature.com
Genetic associations for keratoconus could be useful for understanding disease
pathogenesis and discovering biomarkers for early detection of the disease. We conducted …

RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients

J You, SM Corley, L Wen, C Hodge, R Höllhumer… - Scientific reports, 2018 - nature.com
Keratoconus is a common degenerative corneal disease that can lead to significant visual
morbidity, and both genetic and environmental factors have been implicated in its …

Corneal cross-linking for pediatric keratcoconus review

C Perez-Straziota, RN Gaster, YS Rabinowitz - Cornea, 2018 - journals.lww.com
Purpose: To comprehensively review the available published literature for cross-linking in
the pediatric population. Methods: Review of the literature published in English in PubMed …