Phosphatidylserine in the brain: metabolism and function

HY Kim, BX Huang, AA Spector - Progress in lipid research, 2014 - Elsevier
Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …

Allosteric modulation of glycine receptors

GE Yevenes, HU Zeilhofer - British journal of pharmacology, 2011 - Wiley Online Library
Inhibitory (or strychnine sensitive) glycine receptors (GlyRs) are anion‐selective transmitter‐
gated ion channels of the cys‐loop superfamily, which includes among others also the …

T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids

G Barbara, A Alloui, J Nargeot, P Lory… - Journal of …, 2009 - Soc Neuroscience
Lipoamino acids are anandamide-related endogenous molecules that induce analgesia via
unresolved mechanisms. Here, we provide evidence that the T-type/Cav3 calcium channels …

Function and therapeutic potential of N-acyl amino acids

SA Prakash, RK Kamlekar - Chemistry and physics of lipids, 2021 - Elsevier
N-acyl amino acids (NAAs) are amphiphilic molecules, with different potential fatty acid and
head group moieties. NAAs are the largest family of anandamide congener lipids discovered …

Endocannabinoid‐like N‐arachidonoyl serine is a novel pro‐angiogenic mediator

X Zhang, Y Maor, JF Wang, G Kunos… - British journal of …, 2010 - Wiley Online Library
BACKGROUND AND PURPOSE N‐arachidonoyl serine (ARA‐S) is a recently identified
endocannabinoid‐like lipid with weak affinity for the fully characterized cannabinoid …

N-acyl amino acids (elmiric acids): endogenous signaling molecules with therapeutic potential

SH Burstein - Molecular pharmacology, 2018 - ASPET
The subject of N-acyl amino acid conjugates has been rapidly growing in recent years,
especially with regard to their analgesic and anti-inflammatory actions. The field comprises a …

N‐Acyl amino acids and N‐acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets

M Connor, CW Vaughan… - British journal of …, 2010 - Wiley Online Library
The myriad functions of lipids as signalling molecules is one of the most interesting fields in
contemporary pharmacology, with a host of compounds recognized as mediators of …

N-arachidonyl glycine does not activate G protein–coupled receptor 18 signaling via canonical pathways

VB Lu, HL Puhl, SR Ikeda - Molecular pharmacology, 2013 - ASPET
Recent studies propose that N-arachidonyl glycine (NAGly), a carboxylic analogue of
anandamide, is an endogenous ligand of the G α i/o protein–coupled receptor 18 (GPR18) …

N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities

U Grabiec, F Dehghani - Cannabis and cannabinoid research, 2017 - liebertpub.com
N-arachidonoyl dopamine (NADA) is a member of the family of endocannabinoids to which
several other N-acyldopamines belong as well. Their activity is mediated through various …

Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids

GE Yévenes, HU Zeilhofer - PLoS One, 2011 - journals.plos.org
Glycine receptors (GlyRs) are transmitter-gated anion channels of the Cys-loop superfamily
which mediate synaptic inhibition at spinal and selected supraspinal sites. Although they …