The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

Irritable bowel syndrome with diarrhoea (IBS‐D) and functional diarrhoea (FDr) are the two
major functional bowel disorders characterized by diarrhoea. In spite of their high …

The microbiota-gut-brain axis (MGBA) regulates the reciprocal interaction between chronic
inflammatory bowel and psychiatric disorders. This interaction involves multiple pathways …

Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is
characterized by abdominal pain and an altered defecation pattern. It affects between 5 and …

Functional gastrointestinal disorders—recently renamed into disorders of gut–brain
interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent …

Proteases are an evolutionarily conserved family of enzymes that degrade peptide bonds
and have been implicated in several common gastrointestinal (GI) diseases. Although …

Abnormalities of mast cell structure or function may play prominent roles in irritable bowel
syndrome (IBS) symptom genesis. Mast cells show close apposition to sensory nerves and …

Chronic unexplained gastrointestinal symptoms impact more than 1 in 5 Americans and their
families; these disorders include the irritable bowel syndrome (IBS) and functional …

BACKGROUND: Subtle histopathologic features such as eosinophilia and increased mast
cells have been observed in functional gastrointestinal disorders (FGIDs), including …