Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus
(HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further …

The translation of basic research into improved therapies for breast cancer patients requires
relevant preclinical models that incorporate spontaneous metastasis. We have completed a …

Aberrant activation of a latent embryonic program-known as the epithelial-mesenchymal
transition (EMT)-can endow cancer cells with the migratory and invasive capabilities …

Stem cells have the capacity for self-renewal and differentiation into specialized cells that
form and repopulated all tissues and organs, from conception to adult life. Depending on …

Although chemotherapy is an important therapeutic strategy for cancer treatment, it fails to
eliminate all tumor cells due to intrinsic or acquired drug resistance, which is the most …

Directed cell migration by contact guidance in aligned collagenous extracellular matrix
(ECM) is a critical enabler of breast cancer dissemination. The mechanisms of this process …

Kinase inhibitor resistance often involves upregulation of poorly understood “bypass”
signaling pathways. Here, we show that extracellular proteomic adaptation is one path to …

Transforming growth factor-β (TGF-β) is a potent pleiotropic cytokine that regulates
mammalian development, differentiation, and homeostasis in essentially all cell types and …