Generation of reactive oxygen species and related oxidants is an inevitable consequence of
life. Proteins are major targets for oxidation reactions, because of their rapid reaction rates …

Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related
disorders, including neurodegenerative diseases and ischemic stroke, which are the major …

Protein homeostasis or proteostasis is an essential balance of cellular protein levels
mediated through an extensive network of biochemical pathways that regulate different …

Citrate synthase is a key mitochondrial enzyme that utilizes acetyl-CoA and oxaloacetate to
form citrate in the mitochondrial membrane, which participates in energy production in the …

In the middle of the coronavirus disease 19 (COVID-19) outbreak, the main efforts of the
scientific community are rightly all focused on identifying efficient pharmacological …

Several theories have been postulated, trying to explain why and how living organisms age.
Despite some controversies and still huge open questions, a growing body of evidence …

Early diagnosis of Alzheimer's disease (AD) is a crucial starting point in disease
management. Blood-based biomarkers could represent a considerable advantage in …

The aggregation of β-amyloid (Aβ) peptide in Alzheimer's disease (AD) is characterized by
mitochondrial dysfunction and mitophagy impairment. Mitophagy is a homeostatic …

The aging of the immune system has recently attracted a lot of attention. Immune
senescence describes changes that the immune system undergoes over time. The …