The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial
roles in vasculogenesis and angiogenesis. Angiogenesis is an important mechanism in …

The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …

Background Expression of the colony-stimulating factor 1 (CSF1) gene is elevated in most
tenosynovial giant-cell tumors. This observation has led to the discovery and clinical …

Abstract ABSTRACT: Colony-Stimulating Factor-1 Receptor (CSF1R) is a receptor tyrosine
kinase that controls the differentiation and maintenance of most tissue-resident …

Analyses of compounds in clinical development have shown that ligand efficient-molecules
with privileged physical properties and low dose are less likely to fail in the various stages of …

Histiocytoses are clonal hematopoietic disorders frequently driven by mutations mapping to
the BRAF and MEK1 and MEK2 kinases. Currently, however, the developmental origins of …

Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel
development and homeostasis. VEGFs are predominantly produced by endothelial …

The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF
receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have important …

The specificities of nine approved tyrosine kinase inhibitors (imatinib, dasatinib, nilotinib,
gefitinib, erlotinib, lapatinib, sorafenib, sunitinib, and pazopanib) were determined by activity …

ATP-competitive kinase inhibitors often bind several kinases due to the high conservation of
the ATP binding pocket. Through clustering analysis of a large kinome profiling dataset, we …