Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease
(PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated …

Hypoxia-inducible factor (HIF) plays a crucial role in the response to hypoxia at the cellular,
tissue, and organism level. New agents under development to pharmacologically …

With the rapidly growing demand for mesenchymal stem cell (MSC) therapy, numerous
strategies using MSCs for different diseases have been studied and reported. Because of …

Although peripheral artery disease (PAD) primarily affects large arteries outside the brain,
PAD is also associated with elevated cerebral vulnerabilities, including greater risks for …

Introduction Engraftment of mesenchymal stem cells (MSCs) has emerged as a powerful
candidate for mediating myocardial repair. In this study, we genetically modified MSCs with …

Therapeutic angiogenesis has been considered as a potential strategy for treating
peripheral artery diseases including hind-limb ischemia (HLI); however, no effective drug …

Exercise has a profound effect on cardiovascular disease, particularly through vascular
remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular …

The hypoxia‐inducible factor (HIF) co‐ordinates the adaptive transcriptional response to
hypoxia in metazoan cells. The hypoxic sensitivity of HIF is conferred by a family of oxygen …

Introduction In the present study, we aimed to explore the functional role of Pellino-1 (Peli1)
in inducing neovascularization after myocardial infarction (MI) and hindlimb ischemia (HLI) …