Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

[HTML][HTML] Pathophysiology of obesity and its associated diseases

X Jin, T Qiu, L Li, R Yu, X Chen, C Li, CG Proud… - … Pharmaceutica Sinica B, 2023 - Elsevier
The occurrence of obesity has increased across the whole world. Many epidemiological
studies have indicated that obesity strongly contributes to the development of cancer …

Receptor for advanced glycation end products (RAGE) and mechanisms and therapeutic opportunities in diabetes and cardiovascular disease: insights from human …

L Egaña-Gorroño, R López-Díez, G Yepuri… - Frontiers in …, 2020 - frontiersin.org
Obesity and diabetes are leading causes of cardiovascular morbidity and mortality. Although
extensive strides have been made in the treatments for non-diabetic atherosclerosis and its …

Impact of different ectopic fat depots on cardiovascular and metabolic diseases

D Ferrara, F Montecucco, F Dallegri… - Journal of cellular …, 2019 - Wiley Online Library
A growing body of evidence is pointing out the pathophysiological role of fat accumulation in
different organs. Ectopic fat depots within heart, liver, skeletal muscle, kidney, and pancreas …

Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis

G Livshits, A Kalinkovich - Ageing research reviews, 2019 - Elsevier
Sarcopenia, obesity and their coexistence, obese sarcopenia (OBSP) as well as
atherosclerosis-related cardio-vascular diseases (ACVDs), including chronic heart failure …

Epicardial fat and coronary artery disease: Role of cardiac imaging

M Guglielmo, A Lin, D Dey, A Baggiano, L Fusini… - Atherosclerosis, 2021 - Elsevier
Epicardial adipose tissue (EAT) represents the fat depot located between the myocardium
and the visceral pericardial layer. Far from being an inert tissue, EAT has been recognized …

[HTML][HTML] Recent advances in artificial intelligence for cardiac CT: Enhancing diagnosis and prognosis prediction

F Tatsugami, T Nakaura, M Yanagawa, S Fujita… - Diagnostic and …, 2023 - Elsevier
Recent advances in artificial intelligence (AI) for cardiac computed tomography (CT) have
shown great potential in enhancing diagnosis and prognosis prediction in patients with …

Epicardial adipose tissue and cardiac arrhythmias: focus on atrial fibrillation

M Conte, L Petraglia, S Cabaro, V Valerio… - Frontiers in …, 2022 - frontiersin.org
Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases
with age. AF is strongly associated with an increased risk of stroke, heart failure and …

[HTML][HTML] Obesity and diabetes are major risk factors for epicardial adipose tissue inflammation

V Vyas, H Blythe, EG Wood, B Sandhar, SJ Sarker… - JCI insight, 2021 - ncbi.nlm.nih.gov
BACKGROUND Epicardial adipose tissue (EAT) directly overlies the myocardium, with
changes in its morphology and volume associated with myriad cardiovascular and metabolic …

Inflammation and cardiovascular diseases in the elderly: the role of epicardial adipose tissue

M Conte, L Petraglia, P Poggio, V Valerio… - Frontiers in …, 2022 - frontiersin.org
Human aging is a complex phenomenon characterized by a wide spectrum of biological
changes which impact on behavioral and social aspects. Age-related changes are …