Pathogenic pathways and therapeutic approaches targeting inflammation in diabetic nephropathy

S Rayego-Mateos, JL Morgado-Pascual… - International journal of …, 2020 - mdpi.com
Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting
in elevated cost for public health systems. DN is the main cause of chronic kidney disease …

[HTML][HTML] PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics

HZ Ying, Q Chen, WY Zhang… - Molecular …, 2017 - … .spandidos-publications.com
The platelet‑derived growth factor (PDFG) signaling pathway exerts persistent activation in
response to a variety of stimuli and facilitates the progression of hepatic fibrosis. Since this …

Targeting inflammation in diabetic nephropathy: a tale of hope

JA Moreno, C Gomez-Guerrero, S Mas… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease
(CKD) and end-stage renal disease (ESRD). Beyond the new anti-diabetic drugs that …

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

S Rayego-Mateos, S Campillo… - Clinical …, 2021 - portlandpress.com
Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …

Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats

HO Abou-Hany, H Atef, E Said, HA Elkashef… - Chemico-biological …, 2018 - Elsevier
Diabetic Nephropathy (DN) is one of the main complications associated with diabetes
mellitus. Persistently elevated blood glucose level drives histopathological changes in renal …

Stabilized-chitosan selenium nanoparticles efficiently reduce renal tissue injury and regulate the expression pattern of aldose reductase in the diabetic-nephropathy …

SI Khater, AAR Mohamed, AH Arisha, LLM Ebraheim… - Life Sciences, 2021 - Elsevier
One of the global alarming prevalent metabolic diseases is Type 2 diabetes mellitus (T2DM)
than other diabetes and sustains a substantial burden on public and healthcare systems …

Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats

E Said, SA Zaitone, M Eldosoky… - Chemico-biological …, 2018 - Elsevier
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus. Moreover, it is
amongst the most common causes of end-stage renal failure. Inflammation is a crucial …

A comparative study of the role of crocin and sitagliptin in attenuation of STZ-induced diabetes mellitus and the associated inflammatory and apoptotic changes in …

MM Samaha, E Said, HA Salem - Environmental Toxicology and …, 2019 - Elsevier
Type 1 diabetes mellitus (T1DM) describes a complex group of metabolic disorders
associated with elevated blood glucose levels and increased risks of complications …

Anti-Diabetic and Anti-Nephritic Activities of Grifola frondosa Mycelium Polysaccharides in Diet-Streptozotocin-Induced Diabetic Rats Via Modulation on Oxidative …

L Kou, M Du, P Liu, B Zhang, Y Zhang, P Yang… - Applied biochemistry …, 2019 - Springer
Grifola frondosa is an edible fungus with a variety of potential pharmacological activities.
This study investigates the hypoglycemic, anti-diabetic nephritic, and antioxidant properties …

Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress

Y Tian, H Guo, X Miao, J Xu, R Yang, L Zhao, J Liu… - Cell death & …, 2020 - nature.com
Podocyte injury is the main cause of proteinuria in lupus nephritis (LN). Nestin, an important
cytoskeleton protein, is expressed stably in podocytes and is associated with podocyte …