The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Cardioprotection aims at infarct size reduction and improvement of clinical outcome from
myocardial infarction. The translation of cardioprotection from preclinical and promising …

Remodelling is a response of the myocardium and vasculature to a range of potentially
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …

The success of a primary percutaneous intervention (PCI) in the setting of ST elevation
myocardial infarction depends on the functional and structural integrity of coronary …

Myocardial infarct size is a major determinant of prognosis. Ischaemic preconditioning with
brief coronary occlusion and reperfusion before a sustained period of coronary occlusion …

Background—The effect of β-blockers on infarct size when used in conjunction with primary
percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces …

The atherosclerotic coronary vasculature is not only the culprit but also a victim of
myocardial ischemia/reperfusion injury. Manifestations of such injury are increased vascular …

This review constitutes a critical evaluation of recent publications that have described an
additional mode of action of the P2Y12 receptor antagonist ticagrelor. The effect is mediated …