The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …

Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of
molecules associated with one of the major pathways through which many cytokines exert …

Cytosolic DNA activates cGAS (cytosolic DNA sensor cyclic AMP-GMP synthase)-STING
(stimulator of interferon genes) signaling, which triggers interferon and inflammatory …

New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–
signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling …

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Background Gain-of-function mutations in STING1 underlie a type I interferonopathy termed
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …

This article provides an initial assessment of the many risks posed by the COVID-19
pandemic on the conduct of genuine and transparent elections in the world. It begins with …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-
Goutières syndrome (AGS), but the mechanisms triggering disease in the human central …

Heterozygous missense mutations in coatomer protein subunit α, COPA, cause a syndrome
overlapping clinically with type I IFN-mediated disease due to gain-of-function in STING, a …