Pediatric acute myeloid leukemia (AML) develops from clonal expansion of hematopoietic
precursor cells and is characterized by morphologic and cytomolecular heterogeneity …

Signalling by retinoid compounds is vital for embryonic development, with particular
importance for neurogenesis in the human brain. Retinoids, metabolites of vitamin A, exert …

In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused
to> 60 different partner genes. In order to define a core set of MLL rearranged targets, we …

Ewing's sarcoma is a rare and aggressive malignancy. In the present study, tumor from a
patient with a Ewing's sarcoma with cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) …

To study the prognostic relevance of rare genetic aberrations in acute myeloid leukemia
(AML), such as t (16; 21), international collaboration is required. Two different types of t (16; …

Abstract Changes in gene regulation and expression govern orderly transitions from
hematopoietic stem cells to terminally differentiated blood cell types. These transitions are …

Summary The t (8; 21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO
disrupts normal hematopoietic differentiation. Here, we have investigated its effects on the …

The basic helix–loop–helix transcription factor (bHLH TF) family is involved in tissue
development, cell differentiation, and disease. These factors have transcriptionally positive …

Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on
chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is …

Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We
identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic …