Programmed cell death (PCD) is an essential part of organismal development and plays
fundamental roles in host defense against pathogens and the maintenance of homeostasis …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …

We report here the purification of the third protein factor, Apaf-3, that participates in caspase-
3 activation in vitro. Apaf-3 was identified as a member of the caspase family, caspase-9 …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …

REVIEW Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell
suicide program critical for development, tissue homeostasis, and protection against …

Apoptosis is a form of programmed cell death critical for the development and homeostasis
of multicellular organisms. A key event within the mitochondrial pathway to apoptosis is the …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

We report here the reconstitution of the de novo procaspase-9 activation pathway using
highly purified cytochrome c, recombinant APAF-1, and recombinant procaspase-9. APAF-1 …

Apoptosis or programmed cell death, is essential for the normal functioning and survival of
most multi-cellular organisms. The morphological and biochemical characteristics of …