Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are
considered as specialized immune cells that can be genetically modified to obtain capable …

Microfluidics is an emerging technology that can be employed as a powerful tool for
designing lipid nano-microsized structures for biological applications. Those lipid structures …

Chimaeric antigen receptor (CAR) T cells can generate durable clinical responses in B-cell
haematologic malignancies. The manufacturing of these T cells typically involves their …

A common bottleneck in any drug development process is finding sufficiently accurate
models that capture key aspects of disease development and progression. Conventional …

A lymph node sinus-on-a-chip adhesion microfluidic platform that recapitulates the
hydrodynamic microenvironment of the lymph node subcapsular sinus was engineered. This …

Chimeric antigen receptor (CAR)-T cell therapies have revolutionized cancer treatment,
particularly in hematological malignancies. However, their application to solid tumors is …

Serum deficiency diseases such as alpha-1-antitrypsin deficiency are characterized by
reduced function of serum proteins, caused by deleterious genetic mutations. These …

Lentiviral vectors (LVs) have provided an efficient way to integrate our gene of interest into
eukaryote cells. Human immunodeficiency virus (HIV)-derived LVs have been vastly studied …

Chimeric antigen receptor T (CAR‐T) cell therapy has produced impressive clinical
responses in patients with B‐cell malignancies. Critical to the success of CAR‐T cell …

Viral-based systems are a popular delivery method for introducing exogenous genetic
material into mammalian cells. Unfortunately, the preparation of lentiviruses containing the …