The oncogenic epithelial–mesenchymal transition (EMT) contributes to tumor progression in
various context-dependent ways, including increased metastatic potential, expansion of …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

ABSTRACT C-terminal Binding Proteins (CtBP) 1 and 2 are oncogenic transcriptional co-
regulators overexpressed in many cancer types, with their expression level correlating to …

C-terminal binding proteins (CtBPs) were initially identified as binding partners for the E1A-
transforming proteins. Although the invertebrate genome encodes one CtBP protein, two …

Gene transcription is strictly controlled by transcriptional complexes, which are assemblies
of transcription factors, transcriptional regulators, and co-regulators. Mammalian genomes …

The epicardium is a mesothelial cell layer essential for vertebrate heart development and
pertinent for cardiac repair post-injury in the adult. The epicardium initially forms from a …

Transcriptional corepressor proteins have emerged as an important facet of cancer etiology.
These corepressor proteins are often altered by loss-or gain-of-function mutations, leading …

The mammalian COOH-terminal binding proteins (CtBPs) CtBP1 and CtBP2 are
metabolically regulated transcriptional co-repressors that are degraded upon acute …

Inflammation and apoptosis are two important pathological causes of intervertebral disc
degeneration (IDD). The crosstalk between these two biological processes during IDD …

The CtBP transcriptional corepressors promote cancer cell survival and migration/invasion.
CtBP senses cellular metabolism via a regulatory dehydrogenase domain, and is …