Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

This invited review summarizes work presented in the Russell Ross lecture delivered at the
2012 proceedings of the American Heart Association. We begin with a brief overview of the …

Background: The neural crest contains pluripotent cells that can give rise to neurons and
glial cells of the peripheral nervous system, endocrine cells, connective tissue cells, muscle …

Spermatogonial stem cells (SSCs) maintain spermatogenesis by self-renewal and
generation of spermatogonia committed to differentiation. Under certain in vitro conditions …

Mammalian spermatogenesis is maintained by spermatogonial stem cells (SSCs). However,
since evidentiary assays and unequivocal markers are still missing in non-human primates …

Sertoli cells (Sc) are the sole target of follicle-stimulating hormone (FSH) in the testis and
attain functional maturation post-birth to significantly augment germ cell (Gc) division and …

Primary testicular failure may result in endocrine failure, leading to testosterone deficiency or
exocrine failure causing impaired spermatogenesis and subsequently male infertility. While …

The molecular mechanisms regulating undifferentiated spermatogonial cell proliferation and
differentiation are still not fully understood. Irisin is an exercise-induced hormone, which is a …

Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor critically involved in cell
proliferation, differentiation, and carcinogenesis. Recently, KLF4 was also used for the …

Aspermatogenesis is a severe impairment of spermatogenesis in which germ cells are
completely lacking or present in an immature form, which results in sterility in approximately …